Skip to content
Find an ETF
← All ETFs

Available in 10 markets

iShares Healthcare Innovation UCITS ETF

iShares · IE00BYZK4776

iShares Healthcare Innovation UCITS ETF is an exchange-traded fund (ETF) from iShares, traded under the ticker HEAL (ISIN IE00BYZK4776). In a single purchase you get a diversified basket of holdings rather than a stake in just one business. At its core it is a focused, thematic fund: it concentrates on the health care part of the market, so it lives or dies by that one area rather than the economy as a whole. Underneath, it is about owning small slices of companies, so you share in their growth when they do well — and their falls when they don't. It passively tracks the STOXX Global Breakthrough Healthcare Index index — mirroring that market instead of paying a manager to pick winners, which keeps costs low, and its largest holdings include MODERNA INC, GUARDANT HEALTH INC and NATERA INC. It holds around 222 positions (the ten largest ≈ 16.3%), spreading risk so no single holding decides your outcome. Geographically it leans ~69% United States, ~5.7% Switzerland and ~4.6% Japan. By industry it concentrates most in ~97.9% Health Care and ~1.2% Technology. A focused fund like this is typically held as a smaller 'satellite' position around a broader core — a way to lean into one theme, not usually a portfolio's only holding. Its ongoing charge (TER) is 0.4% a year — about €40 a year on a €10,000 holding, taken automatically from the fund. Income such as dividends is automatically reinvested inside the fund (an accumulating share class), so returns compound without you doing anything. It holds the underlying investments directly (physical replication); it is domiciled in Ireland and UCITS-regulated, a European standard built to protect everyday investors and trades in USD. On the standard KID risk scale it is rated 6 out of 7 and its price has swung about 41.2% over the past year, which describes how much its price tends to move rather than whether it is good. It launched in 2016, and its KID suggests a holding period of medium to long term. Like any investment, it can lose value as well as gain, and what it did before does not predict what it will do next. (Fund data sourced from iShares.)

· Tracks the STOXX Global Breakthrough Healthcare Index index ?
Equity ?Accumulating ?Physical ?Ireland ?
Mid-range feeReinvests dividendsOwns the shares directlyGlobalBroadly spread
Fund size (AUM) ?
€991.9M
Risk level (SRI) ?
6 / 7 · High
1-year return ?
+23.5%
Total return · to 2026-07-16
Yearly fee (TER) ?
0.40%
All-in cost ≈ 0.40%

About this fund

What you own

The STOXX Global Breakthrough Healthcare Index index is the benchmark this fund aims to copy. By holding it, this fund gives you a stake in around 222 companies across Global in a single purchase.

Dividends

The fund automatically reinvests dividends back into itself, so your holding grows without cash payouts.

Read more

Rolling the dividends straight back in means your money compounds automatically, with nothing for you to reinvest by hand. The flip side is there is no cash income; the growth simply shows up as a higher fund value. Note that reinvested dividends can still be taxable in some countries even though you never receive the cash — the rules depend on where you live.

How it works

The fund actually buys every share in the index it tracks (full replication).

Read more

Owning every holding keeps things transparent — what is in the index is what the fund actually owns. It can be a touch costlier to run for indexes with thousands of tiny positions, since the fund has to buy and maintain them all. There is no swap bank involved, so there is no extra “what if the partner fails” question to weigh.

Cost

0.40%Yearly fee (TER)
0.40%All-in cost

The yearly running cost of the fund, shown as a % of your money. €0.20 per €100 a year at 0.20%. Lower is cheaper.

Read more

It is skimmed quietly from inside the fund a little each day, so you never get a bill — but it drags on your return every year you hold. On a broad index ETF it is usually a small fraction of a percent; the gap between a cheap and a pricey fund looks tiny on day one but compounds over decades, which is why it is worth a glance.

Fund facts

Index tracked ?
STOXX Global Breakthrough Healthcare Index
Replication ?
Physical
Full — buys every share
Regulation ?
UCITS
Yes
Launched
Sep 2016
10-year track record
Recommended holding period
medium to long term

Performance

55.768.280.793.3106202120232026

Growth of $100 invested — the line starts at $100.

iShares Healthcare Innovation UCITS ETF

End-of-day prices, rebased to a common start so the shapes are comparable. Past performance does not predict future results.

YTD+7.9%
1 year+23.5%
3 years+9.4%
5 years-1.3%

Return, year by year

-22.3
-0.6
+7.1
+14.3
'22'23'24'25
2 of 4 up yearsBest: 2025 +14.3%Worst: 2022 -22.3%Calendar-year total returns, in USD

How bumpy has it been?

41.2%
Volatility (1y) ?
How much the price swings year to year — lower is calmer.
-19.9%
Worst drop (3y) ?
The biggest fall from a peak over the last three years.

The bigger picture

-6.4%
Since inception
Total growth since launch — about -1.3% a year.
+25.2%
Best 12 months
The strongest one-year stretch on record.
-33.5%
Worst 12 months
The weakest one-year stretch on record.
-42.2%
Worst fall on record ?
It has not fully recovered yet.

What's inside

By sector ?

Health Care97.9%
Technology1.2%
Industrials0.4%
Other0.2%
Real Estate0.2%

The 10 biggest holdings make up 16.3% of the fund — the rest is spread across roughly 212 more companies.

Top 10 holdings

#CompanyWeight
1MODERNA INC2.3%
2GUARDANT HEALTH INC1.7%
3NATERA INC1.7%
4ROIVANT SCIENCES LTD1.6%
5ILLUMINA INC1.6%
6LONZA GROUP AG1.5%
7ABBVIE INC1.5%
8GENMAB1.5%
9MEDPACE HOLDINGS INC1.5%
10IQVIA HOLDINGS INC1.5%

Where to buy this fund

Set from your language & location — change it if it's wrong.

Where it trades

ExchangeTickerCurrency
LSEHEALUSD★ Primary
CHF listings
SIX2B78CHF
SIXHEALCHF
EUR listings
Borsa ItalianaHEALEUR
Euronext AmsterdamHEALEUR
Frankfurt2B78EUR
USD listings
B2HEALUSD
B2HEALEURUSD
B32B78DUSD
B3DRDRLUSD
B3HEALAUSD
B3HEALMUSD
B3HEALZUSD
B3HEALLUSD
B4HEALEURUSD
B4HEALUSDUSD
BQHEALLUSD
BQHEALMUSD
BW2B78USD
BWHEALUSD
CCHEALCLUSD
CEHEALCLUSD
CIHEALCLUSD
E1HEALUSDUSD
E1HEALMXNUSD
E1HEALGBXUSD
E1HEALEURUSD
EBDRDRLUSD
EBHEALAUSD
EBHEALLUSD
EBHEALZUSD
EB2B78DUSD
EPHEALUSDUSD
EPHEALMXNUSD
EPHEALGBXUSD
EPHEALEURUSD
EUHEALGBXUSD
EUHEALUSDUSD
EUHEALMXNUSD
EUHEALEURUSD
EZHEALEURUSD
EZHEALMXNUSD
EZHEALUSDUSD
EZHEALGBXUSD
GD2B78USD
GF2B78USD
GH2B78USD
GM2B78USD
GS2B78USD
GT2B78USD
GZ2B78USD
I2HEALAUSD
I22B78DUSD
ITISFF402USD
IXHEALZUSD
IXHEALLUSD
IXHEALAUSD
IXDRDRLUSD
IX2B78DUSD
L1HEALZUSD
L1HEALMUSD
L1HEALLUSD
L1HEALAUSD
L12B78DUSD
L3HEALZUSD
L3HEALMUSD
L3HEALLUSD
L3HEALAUSD
L3DRDRLUSD
L32B78DUSD
LA2B78USD
London Stock ExchangeHEALUSD
LSEDRDRUSD
LU2B78USD
MFHEALNUSD
MMHEALNUSD
MUHEALNUSD
POHEALZUSD
POHEALMUSD
POHEALLUSD
POHEALAUSD
PODRDRLUSD
PO2B78DUSD
PQBLKIFUSD
PZDRDRUSD
PZHEALUSD
QEHEALAUSD
QE2B78DUSD
QT2B78USD
QXHEALZUSD
QXHEALLUSD
QXHEALAUSD
QXDRDRLUSD
QX2B78DUSD
S12B78DUSD
S1HEALLUSD
S42B78DUSD
SEHEALUSD
T22B78USD
T2DRDRUSD
T2HEALUSD
TH2B78USD
TQHEALLUSD
USBLKIFUSD
UVBLKIFUSD
WTHEALUSD
WTDRDRUSD
WT2B78USD
X1HEALMXNUSD
X2HEALUSDUSD
X2HEALMXNUSD
X2HEALGBXUSD
X2HEALEURUSD
X9HEALEURUSD
X9HEALGBXUSD
X9HEALUSDUSD
XAHEALUSDUSD
XAHEALMXNUSD
XAHEALGBXUSD
XAHEALEURUSD
XEHEALEURUSD
XEHEALGBXUSD
XEHEALMXNUSD
XEHEALUSDUSD
XFHEALUSDUSD
XFHEALMXNUSD
XFHEALGBXUSD
XFHEALEURUSD
XGHEALEURUSD
XGHEALGBXUSD
XGHEALMXNUSD
XGHEALUSDUSD
XHHEALUSDUSD
XHHEALMXNUSD
XHHEALGBXUSD
XHHEALEURUSD
XJHEALUSDUSD
XJHEALMXNUSD
XJHEALGBXUSD
XJHEALEURUSD
XLHEALUSDUSD
XLHEALMXNUSD
XLHEALGBXUSD
XLHEALEURUSD
XOHEALEURUSD
XOHEALGBXUSD
XOHEALMXNUSD
XOHEALUSDUSD
XQHEALMXNUSD
XSHEALEURUSD
XSHEALGBXUSD
XSHEALMXNUSD
XSHEALUSDUSD
XUHEALUSDUSD
XUHEALMXNUSD
XUHEALGBXUSD
XUHEALEURUSD
XVHEALUSDUSD
XVHEALMXNUSD
XVHEALGBXUSD
XVHEALEURUSD
XWHEALUSDUSD
XWHEALMXNUSD
XWHEALGBXUSD
XWHEALEURUSD
XXHEALEURUSD
XXHEALGBXUSD
XXHEALMXNUSD
XXHEALUSDUSD
XZHEALMXNUSD
For serious comparison — full data holdings, percentiles, advanced risk, tilt, flows

Full holdings

As of 2026-07-16 · the fund's own published holdings.

#CompanyWeight
1MODERNA INC2.3%
2GUARDANT HEALTH INC1.7%
3NATERA INC1.7%
4ROIVANT SCIENCES LTD1.6%
5ILLUMINA INC1.6%
6LONZA GROUP AG1.5%
7ABBVIE INC1.5%
8GENMAB1.5%
9MEDPACE HOLDINGS INC1.5%
10IQVIA HOLDINGS INC1.5%
11JOHNSON & JOHNSON1.5%
12EDWARDS LIFESCIENCES CORP1.4%
13JAZZ PHARMACEUTICALS PLC1.4%
14AMGEN INC1.4%
15MERCK & CO INC1.4%
16ARGENX1.4%
17NEUROCRINE BIOSCIENCES INC1.4%
18REVVITY INC1.4%
19ABBOTT LABORATORIES1.4%
20EXELIXIS INC1.4%
21BIOGEN INC1.4%
22NOVARTIS AG1.4%
23SHIONOGI LTD1.4%
24GLAXOSMITHKLINE1.4%
25GILEAD SCIENCES INC1.4%
26DANAHER CORP1.4%
27CELLTRION INC1.4%
28ARROWHEAD PHARMACEUTICALS INC1.4%
29INTUITIVE SURGICAL INC1.3%
30MEDTRONIC PLC1.3%
31BRISTOL MYERS SQUIBB1.3%
32ROCHE PS PAR AG1.3%
33AGILENT TECHNOLOGIES INC1.3%
34UCB SA1.3%
35CHARLES RIVER LABORATORIES INTERNA1.2%
36BIO TECHNE CORP1.2%
37DEXCOM INC1.2%
38INSULET CORP1.2%
39PFIZER INC1.2%
40SAMSUNG BIOLOGICS LTD1.2%
41BOSTON SCIENTIFIC CORP1.2%
42AXSOME THERAPEUTICS INC1.1%
43HALOZYME THERAPEUTICS INC1.1%
44ALKERMES1.0%
45ORION CLASS B1.0%
46PRO MEDICUS LTD0.9%
47QIAGEN NV0.9%
48EISAI LTD0.9%
49TG THERAPEUTICS INC0.9%
50SHIMADZU CORP0.8%
51REPLIGEN CORP0.8%
52PTC THERAPEUTICS INC0.8%
53IPSEN SA0.8%
54RHYTHM PHARMACEUTICALS INC0.8%
55LANTHEUS HOLDINGS INC0.7%
56SARTORIUS PREF AG0.7%
57TEMPUS AI INC CLASS A0.7%
58LIGAND PHARMACEUTICALS INC0.7%
59BIO RAD LABORATORIES INC CLASS A0.7%
60XENON PHARMACEUTICALS INC0.7%
61TWIST BIOSCIENCE CORP0.6%
62ASAHI INTECC LTD0.6%
63DIANTHUS THERAPEUTICS INC0.6%
64SYSMEX CORP0.6%
65CG ONCOLOGY INC0.5%
66VERACYTE INC0.5%
6710X GENOMICS INC CLASS A0.5%
68LIVANOVA PLC0.5%
69SICHUAN KELUN-BIOTECH BIOPHARM LTD0.5%
70SECTRA CLASS B0.5%
71BIOMERIEUX SA0.4%
72CATALYST PHARMACEUTICALS INC0.4%
73SIEGFRIED HOLDING AG0.4%
74IDEAYA BIOSCIENCES INC0.4%
75ADAPTIVE BIOTECHNOLOGIES CORP0.4%
76ACADIA PHARMACEUTICALS INC0.4%
77IMMUNITYBIO INC0.4%
78WUXI XDC CAYMAN INC0.4%
79RELAY THERAPEUTICS INC0.3%
80BACHEM HOLDING AG0.3%
81ZEALAND PHARMA0.3%
82MAXIMUS INC0.3%
83KINIKSA PHARMACEUTICALS INTERNATIO0.3%
84TECAN GROUP AG0.3%
85GRAIL INC0.3%
86IMMUNOME INC0.3%
87SUPERNUS PHARMACEUTICALS INC0.3%
88ARCUS BIOSCIENCES INC0.3%
89BIOCRYST PHARMACEUTICALS INC0.3%
90ABL BIO INC0.3%
91CARIS LIFE SCIENCES INC0.3%
92ALUMIS INC0.3%
93AXOGEN INC0.3%
94BAVARIAN NORDIC0.3%
95JEOL LTD0.3%
96ADMA BIOLOGICS INC0.2%
97VIRIDIAN THERAPEUTICS ORS INC0.2%
98RECURSION PHARMACEUTICALS INC CLAS0.2%
99NEOGEN CORP0.2%
100SAREPTA THERAPEUTICS INC0.2%
101STOKE THERAPEUTICS INC0.2%
102ELEKTA B0.2%
103ASTRANA HEALTH INC0.2%
104HARMONY BIOSCIENCES HLDG INC0.2%
105D&D PHARMATECH INC0.2%
106DUALITY BIOTHERAPEUTICS INC0.2%
107CORVEL CORP0.2%
108SK BIOPHARMACEUTICALS LTD0.2%
109INTERNATIONAL WORKPLACE GROUP PLC0.2%
110ABCELLERA BIOLOGICS INC0.2%
111AURINIA PHARMACEUTICALS INC0.2%
112SYNDAX PHARMACEUTICALS INC0.2%
113NOVOCURE LTD0.2%
114H. LUNDBECK CLASS B0.2%
115UROGEN PHARMA LTD0.2%
116ATAIBECKLEY INC0.2%
117JIANGSU HENGRUI PHARMACEUTICALS LT0.2%
118FORTREA HOLDINGS INC0.2%
119ABSCI CORP0.2%
120GENEDX HOLDINGS CORP CLASS A0.2%
121ATRICURE INC0.2%
122DIASORIN0.2%
123IOVANCE BIOTHERAPEUTICS INC0.2%
124SHANGHAI MICROPORT MEDBOT CLASS H0.2%
125TAYSHA GENE THERAPIES INC0.2%
126NOVAVAX INC0.2%
127IDORSIA N LTD0.2%
128NEUREN PHARMACEUTICALS LTD0.2%
129NUVATION BIO INC CLASS A0.2%
130THE UNITED LABORATORIES INTERNATIO0.2%
131BIOARCTIC CLASS B0.2%
132CAREDX INC0.2%
133VIR BIOTECHNOLOGY INC0.2%
134ANAPTYSBIO INC0.2%
135BIOLIFE SOLUTIONS INC0.2%
136VORONOI INC0.2%
137SHANGHAI HENLIUS BIOTECH INC H0.2%
138NANOBIOTIX SA0.2%
139QUIDELORTHO CORP0.1%
140INTEGRA LIFESCIENCES HOLDINGS CORP0.1%
141HUTCHMED (CHINA) LTD0.1%
142PHARMA MAR SA0.1%
143ZYMEWORKS INC0.1%
144MEDINCELL SA0.1%
145CHEMOMETEC0.1%
146JINHAI MEDICAL TECHNOLOGY LTD0.1%
147DOTTIKON ES HOLDING AG0.1%
148LAKEFRONT BIOTHER NV0.1%
149TANDEM DIABETES CARE INC0.1%
150ST PHARM LTD0.1%
151SCHRODINGER INC0.1%
152PHARMING GROUP NV0.1%
153OXFORD NANOPORE TECHNOLOGIES PLC0.1%
154HBM HOLDINGS LTD0.1%
155EVOTEC0.1%
156KURA ONCOLOGY INC0.1%
157POLYPEPTIDE N AG0.1%
158CERTARA INC0.1%
159OSCOTEC INC0.1%
160USD CASH0.1%
161OXFORD BIOMEDICA PLC0.1%
162XVIVO PERFUSION0.1%
163JANUX THERAPEUTICS INC0.1%
164ECKERT & ZIEGLER0.1%
165MARAVAI LIFESCIENCES HOLDINGS INC0.1%
166CASTLE BIOSCIENCES INC0.1%
167RAYSEARCH LABORATORIES CLASS B0.1%
168DYNAVOX GROUP0.1%
169SEEGENE INC0.1%
170SK BIOSCIENCE LTD0.1%
171ROCHE HOLDING AG0.1%
172BRAINSWAY LTD0.1%
173REGENXBIO INC0.1%
174HANGZHOU TIGERMED CONSULTING LTD H0.1%
175MYRIAD GENETICS INC0.1%
176LEPU BIOPHARMA LTD H0.1%
177EVOLENT HEALTH INC CLASS A0.1%
178CYTEK BIOSCIENCES INC0.1%
179ARVINAS INC0.1%
180JAPAN LIFELINE LTD0.1%
181LUNIT INC0.1%
182PACIFIC BIOSCIENCES OF CALIFORNIA0.1%
183SUTRO BIOPHARMA INC0.1%
184SHANGHAI JUNSHI BIOSCIENCES LTD H0.1%
185VALNEVA0.1%
186PROTHENA PLC0.0%
187VANDA PHARMACEUTICALS INC0.0%
188EIKEN CHEMICAL LTD0.0%
189EDITAS MEDICINE INC0.0%
190FATE THERAPEUTICS INC0.0%
191GUBRA0.0%
192PHC HOLDINGS CORP0.0%
193ORASURE TECHNOLOGIES INC0.0%
194STANDARD BIOTOOLS INC0.0%
195VITALHUB CORP0.0%
196MACROGENICS INC0.0%
197JOINN LABORATORIES (CHINA) CLASS H0.0%
198SIMULATIONS PLUS INC0.0%
199EUR CASH0.0%
200JPY CASH0.0%
201DKK CASH0.0%
202LYELL IMMUNOPHARMA INC0.0%
203ADC THERAPEUTICS SA0.0%
204GBP CASH0.0%
205CASH COLLATERAL USD HSBFT0.0%
206KRW CASH0.0%
207NKGEN BIOTECH KOREA0.0%
208CHF CASH0.0%
209CAD CASH0.0%
210INR CASH0.0%
211HKD CASH0.0%
212AUD CASH0.0%
213SEK CASH0.0%
214TWD CASH0.0%
215ILS CASH0.0%
216NOK CASH0.0%
217ARCELLX INC CVR0.0%
218HOLOGIC INC0.0%
219OMNIAB INC $12.50 VESTING Prvt0.0%
220OMNIAB INC $15.00 VESTING Prvt0.0%
221RUSSELL 2000 EMINI CME SEP 260.0%
222E-MINI HEALTH CARE SECTOR SEP 260.0%

⭳ Download full holdings (CSV)

How it ranks vs peers

🪙 Cheaper than 0% of similar ETFs💰 All-in cost cheaper than 0%📈 Higher 1-yr return than 100%📈 Higher 3-yr return than 100%📈 Higher 5-yr return than 0%📊 Beat its category by 6.2% (1-yr) (category average +17.3%)📊 Beat its category by 3.0% (3-yr) (category average +6.3%)📊 Behind its category by 5.6% (5-yr) (category average +4.3%)

Versus the Equity (stocks) · Global · Health Care · USD ETFs we track.

Advanced risk

0.39
Sortino (3y) ?
0.47
Calmar (3y) ?
23.4%
Downside deviation ?
73%
Up months (hit rate) ?
$9.77
52-week high ?
$7.71
52-week low ?

Concentration depth

~96 ?
Effective number of holdings

Roughly 222 companies are held, but the largest names carry most of the weight — so it behaves like ~96 equal-sized positions.

Tilt vs a world tracker

Health Care+88.6
Technology-28.0
Financials-16.3
Industrials-11.2
Consumer Discretionary-9.0
Communication Services-8.2

Percentage points over / under a broad world-equity tracker (not a licensed benchmark).

Similar funds

We found 6 funds that do much the same job as this one. To pick them we matched this fund's asset class and region, then show how close each match is below.

Matched on🌍 Global stocks
Compare side by side
6 similar funds
iShares Healthcare Innovation UCITS ETFiSharesYou're viewingiShares Core MSCI World UCITS ETFiSharesBroader matchiShares Core MSCI World UCITS ETFiSharesBroader matchiShares Core MSCI World UCITS ETFiSharesBroader matchiShares Core MSCI World UCITS ETFiSharesBroader matchState Street® SPDR® Portfolio Developed World ex-US ETFSPDRBroader matchiShares MSCI ACWI UCITS ETFiSharesBroader match
Why it's similarThis is the fund on this page.
StocksPhysicalCheaper fee
Tracks a different index in the same category.
StocksPhysicalCheaper fee
Tracks a different index in the same category.
StocksPhysicalCheaper fee
Tracks a different index in the same category.
StocksAccumulatingPhysicalCheaper fee
Tracks a different index in the same category.
StocksPhysicalCheaper fee
Tracks a different index in the same category.
StocksPhysicalCheaper fee
Tracks a different index in the same category.
Index trackedSTOXX Global Breakthrough Healthcare IndexMSCI WorldMSCI WorldMSCI WorldMSCI WorldS&P Developed Ex-U.S. BMI IndexMSCI ACWI
Yearly fee (TER)0.40%0.30%0.30%0.20%0.20%0.03%0.20%
All-in cost0.40%0.30%0.00%0.00%0.20%0.00%0.00%
Fund size€991.9M€172B€146.5B€128.1B€127.6B€34.7B€30.7B
DomicileIrelandIrelandIrelandIrelandIrelandUnited StatesIreland
ReplicationPhysical (full)Physical (full)Physical (full)Physical (full)Physical (full)Physical (full)Physical (full)
3-yr return p.a.+9.4%+17.0%+17.8%+18.3%+14.1%
5-yr return p.a.-1.3%+10.1%+9.3%+11.3%+6.2%
# holdings2221,3561,3561,3561,3562,4691,738

The fund on this page stays pinned on the left — scroll or use ‹ › to compare it against each one.

Open the full comparison tool →
Data as of 2026-07-16 · Source: issuer data, compiled by Finance Hamster

New to ETFs? Start with the basics →

Finance Hamster provides educational information about ETFs and investing. It is not investment, tax, or legal advice, and not a recommendation to buy or sell any security. Markets carry risk; do your own research or consult a licensed adviser.