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State Street® SPDR® S&P® Pharmaceuticals ETF
State Street® SPDR® S&P® Pharmaceuticals ETF is an exchange-traded fund (ETF) from SPDR, traded under the ticker XPH (ISIN US78464A7220). One trade buys a whole basket of holdings, so your money is spread out instead of riding on a single company. At its core it is a focused, thematic fund: it concentrates on the health care part of the market,…
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About this fund
What you own
The S&P Pharmaceuticals Select Industry Index index is the benchmark this fund aims to copy. By holding it, this fund gives you a stake in around 67 companies across Other in a single purchase.
How it works
The fund actually buys every share in the index it tracks (full replication).
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Owning every holding keeps things transparent — what is in the index is what the fund actually owns. It can be a touch costlier to run for indexes with thousands of tiny positions, since the fund has to buy and maintain them all. There is no swap bank involved, so there is no extra “what if the partner fails” question to weigh.
Cost
The yearly running cost of the fund, shown as a % of your money. Lower is cheaper.
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For example, a 0.20% fee works out at €0.20 a year for every €100 invested — that’s a generic illustration of the mechanic, not this fund’s own fee. It is skimmed quietly from inside the fund a little each day, so you never get a bill — but it drags on your return every year you hold. On a broad index ETF it is usually a small fraction of a percent; the gap between a cheap and a pricey fund looks tiny on day one but compounds over decades, which is why it is worth a glance.
Fund facts
Performance
Growth of $100 invested — the line starts at $100.
End-of-day prices, rebased to a common start so the shapes are comparable. Past performance does not predict future results.
Return, year by year
How bumpy has it been?
The bigger picture
What's inside
By sector ?
The 10 biggest holdings make up 21.7% of the fund — the rest is spread across roughly 57 more companies.
Top 10 holdings
| # | Company | Weight |
|---|---|---|
| 1 | DEFINIUM THERAPEUTICS INC | 2.9% |
| 2 | MBX BIOSCIENCES INC | 2.8% |
| 3 | ALUMIS INC | 2.0% |
| 4 | ENLIVEN THERAPEUTICS INC | 2.0% |
| 5 | TREVI THERAPEUTICS INC | 2.0% |
| 6 | AMYLYX PHARMACEUTICALS INC | 2.0% |
| 7 | MAZE THERAPEUTICS INC | 2.0% |
| 8 | VERADERMICS INC | 2.0% |
| 9 | ATAIBECKLEY INC | 2.0% |
| 10 | LIGAND PHARMACEUTICALS | 1.9% |
Where to buy this fund
Set from your language & location — change it if it's wrong.
Where it trades
| Exchange | Ticker | Currency | |
|---|---|---|---|
| NYSE | XPH | USD | ★ Primary |
| EUR listings | |||
| Frankfurt | SSGE | EUR | |
| USD listings | |||
| B2 | XPHUSD | USD | |
| B4 | XPHUSD | USD | |
| E1 | XPHGBP | USD | |
| E1 | XPHRUB | USD | |
| E1 | XPHUSD | USD | |
| EO | XPHRUB | USD | |
| EU | XPH1 | USD | |
| EU | XPHGBP | USD | |
| EU | XPHRUB | USD | |
| EU | XPHUSD | USD | |
| GH | SSGE | USD | |
| GI | SSGE | USD | |
| MF | XPH* | USD | |
| MM | XPH* | USD | |
| MU | XPH* | USD | |
| NYSE Arca | XPH | USD | |
| OC | XPH | USD | |
| TH | SSGE | USD | |
| UA | XPH | USD | |
| UB | XPH | USD | |
| UC | XPH | USD | |
| UD | XPH | USD | |
| UF | XPH | USD | |
| UM | XPH | USD | |
| US | XPH | USD | |
| UT | XPH | USD | |
| UX | XPH | USD | |
| VF | XPH | USD | |
| VG | XPH | USD | |
| VJ | XPH | USD | |
| VK | XPH | USD | |
| VP | XPH | USD | |
| VY | XPH | USD | |
| X2 | XPHUSD | USD | |
| XA | XPHGBP | USD | |
| XA | XPHRUB | USD | |
| XA | XPHUSD | USD | |
| XB | XPHUSD | USD | |
| XE | XPHUSD | USD | |
| XE | XPHRUB | USD | |
| XE | XPHGBP | USD | |
| XF | XPHGBP | USD | |
| XF | XPHRUB | USD | |
| XF | XPHUSD | USD | |
| XG | XPHUSD | USD | |
| XG | XPHRUB | USD | |
| XG | XPHGBP | USD | |
| XH | XPHGBP | USD | |
| XH | XPHRUB | USD | |
| XH | XPHUSD | USD | |
| XJ | XPHUSD | USD | |
| XJ | XPHRUB | USD | |
| XJ | XPHGBP | USD | |
| XL | XPHGBP | USD | |
| XL | XPHRUB | USD | |
| XL | XPHUSD | USD | |
| XO | XPHGBP | USD | |
| XO | XPHRUB | USD | |
| XO | XPHUSD | USD | |
| XQ | XPHUSD | USD | |
| XQ | XPHRUB | USD | |
| XQ | XPHGBP | USD | |
| XS | XPHGBP | USD | |
| XS | XPHUSD | USD | |
| XT | XPHRUB | USD | |
| XU | XPHGBP | USD | |
| XU | XPHRUB | USD | |
| XU | XPHUSD | USD | |
| XV | XPHUSD | USD | |
| XV | XPHRUB | USD | |
| XV | XPHGBP | USD | |
| XW | XPHGBP | USD | |
| XW | XPHRUB | USD | |
| XW | XPHUSD | USD | |
| XX | XPHUSD | USD | |
| XX | XPHRUB | USD | |
| XX | XPHGBP | USD | |
| XZ | XPHGBP | USD | |
| XZ | XPHRUB | USD | |
| XZ | XPHUSD | USD | |
For serious comparison — full data holdings, percentiles, advanced risk, tilt, flows
Full holdings
As of 2026-07-20 · the fund's own published holdings.
| # | Company | Weight |
|---|---|---|
| 1 | DEFINIUM THERAPEUTICS INC | 2.9% |
| 2 | MBX BIOSCIENCES INC | 2.8% |
| 3 | ALUMIS INC | 2.0% |
| 4 | ENLIVEN THERAPEUTICS INC | 2.0% |
| 5 | TREVI THERAPEUTICS INC | 2.0% |
| 6 | AMYLYX PHARMACEUTICALS INC | 2.0% |
| 7 | MAZE THERAPEUTICS INC | 2.0% |
| 8 | VERADERMICS INC | 2.0% |
| 9 | ATAIBECKLEY INC | 2.0% |
| 10 | LIGAND PHARMACEUTICALS | 1.9% |
| 11 | NEKTAR THERAPEUTICS | 1.9% |
| 12 | HARROW INC | 1.9% |
| 13 | CRINETICS PHARMACEUTICALS IN | 1.8% |
| 14 | NUVATION BIO INC | 1.8% |
| 15 | EDGEWISE THERAPEUTICS INC | 1.8% |
| 16 | LIQUIDIA CORP | 1.8% |
| 17 | CORCEPT THERAPEUTICS INC | 1.8% |
| 18 | EYEPOINT INC | 1.8% |
| 19 | WAVE LIFE SCIENCES LTD | 1.7% |
| 20 | OCULAR THERAPEUTIX INC | 1.7% |
| 21 | AMNEAL PHARMACEUTICALS INC | 1.7% |
| 22 | ELANCO ANIMAL HEALTH INC | 1.7% |
| 23 | TARSUS PHARMACEUTICALS INC | 1.6% |
| 24 | PACIRA BIOSCIENCES INC | 1.6% |
| 25 | JOHNSON + JOHNSON | 1.6% |
| 26 | COLLEGIUM PHARMACEUTICAL INC | 1.6% |
| 27 | VIATRIS INC | 1.6% |
| 28 | MERCK + CO. INC. | 1.6% |
| 29 | JAZZ PHARMACEUTICALS PLC | 1.6% |
| 30 | ELI LILLY + CO | 1.6% |
| 31 | INDIVIOR PHARMACEUTICALS INC | 1.6% |
| 32 | SUPERNUS PHARMACEUTICALS INC | 1.6% |
| 33 | ROYALTY PHARMA PLC CL A | 1.6% |
| 34 | HARMONY BIOSCIENCES HOLDINGS | 1.6% |
| 35 | ANI PHARMACEUTICALS INC | 1.6% |
| 36 | BRISTOL MYERS SQUIBB CO | 1.5% |
| 37 | OMEROS CORP | 1.5% |
| 38 | ORGANON + CO | 1.5% |
| 39 | ESPERION THERAPEUTICS INC | 1.5% |
| 40 | BIOAGE LABS INC | 1.5% |
| 41 | PRESTIGE CONSUMER HEALTHCARE | 1.5% |
| 42 | PERRIGO CO PLC | 1.5% |
| 43 | AXSOME THERAPEUTICS INC | 1.5% |
| 44 | XERIS BIOPHARMA HOLDINGS INC | 1.5% |
| 45 | INNOVIVA INC | 1.4% |
| 46 | ZOETIS INC | 1.4% |
| 47 | PFIZER INC | 1.4% |
| 48 | PHIBRO ANIMAL HEALTH CORP A | 1.4% |
| 49 | ETON PHARMACEUTICALS INC | 1.4% |
| 50 | RAPPORT THERAPEUTICS INC | 1.3% |
| 51 | ARVINAS INC | 1.3% |
| 52 | AMPHASTAR PHARMACEUTICALS IN | 1.2% |
| 53 | ZEVRA THERAPEUTICS INC | 1.2% |
| 54 | ALTO NEUROSCIENCE INC | 1.2% |
| 55 | CORMEDIX INC | 1.1% |
| 56 | PHATHOM PHARMACEUTICALS INC | 1.1% |
| 57 | SEPTERNA INC | 1.0% |
| 58 | RELMADA THERAPEUTICS INC | 1.0% |
| 59 | THERAVANCE BIOPHARMA INC | 0.9% |
| 60 | ACLARIS THERAPEUTICS INC | 0.9% |
| 61 | LB PHARMACEUTICALS INC | 0.8% |
| 62 | AQUESTIVE THERAPEUTICS INC | 0.8% |
| 63 | FULCRUM THERAPEUTICS INC | 0.7% |
| 64 | LEXICON PHARMACEUTICALS INC | 0.6% |
| 65 | EVOLUS INC | 0.5% |
| 66 | SSI US GOV MONEY MARKET CLASS | 0.1% |
| 67 | US DOLLAR | 0.0% |
How it ranks vs peers
Versus the Equity (stocks) · Other · USD ETFs we track.
Advanced risk
Concentration depth
Roughly 67 companies are held, but the largest names carry most of the weight — so it behaves like ~60 equal-sized positions.
Tilt vs a world tracker
Percentage points over / under a broad world-equity tracker (not a licensed benchmark).
Similar funds
We found 6 funds that do much the same job as this one. To pick them we matched this fund's asset class and region, then show how close each match is below.
| State Street® SPDR® S&P® Pharmaceuticals ETFSPDRYou're viewing | State Street® Technology Select Sector SPDR® ETFSPDRBroader match | Schwab International Equity ETFSchwabBroader match | Invesco S&P 500 UCITS ETF AccInvescoBroader match | State Street® Financial Select Sector SPDR® ETFSPDRBroader match | State Street® SPDR® S&P® 500 MXN Hdg UCITS ETF (Acc)SPDRBroader match | State Street® SPDR® S&P® 500 GBP Hdg UCITS ETF (Dist)SPDRBroader match | |
|---|---|---|---|---|---|---|---|
| Why it's similar | This is the fund on this page. | StocksUnknownPhysicalCheaper fee Tracks a different index in the same category. | StocksUnknownPhysicalCheaper fee Tracks a different index in the same category. | StocksCheaper fee Tracks a different index in the same category. | StocksUnknownPhysicalCheaper fee Tracks a different index in the same category. | StocksPhysicalCheaper fee Tracks a different index in the same category. | StocksPhysicalCheaper fee Tracks a different index in the same category. |
| Index tracked | S&P Pharmaceuticals Select Industry Index | Technology Select Sector Index | FTSE Developed ex US Index | S&P 500® Total Return (Net) Index | Financial Select Sector Index | ® ® S&p® 500 Mxn Hdg | ® ® S&p® 500 Hdg |
| Yearly fee (TER) | 0.35% | 0.08% | 0.03% | 0.05% | 0.08% | 0.05% | 0.05% |
| All-in cost | 0.00% | 0.00% | 0.00% | 0.12% | 0.00% | 0.06% | 0.06% |
| Fund size | €417.5M | €100.5B | €57.5B | €50.3B | €48.7B | €36.6B | €36.6B |
| Domicile | United States | United States | United States | Ireland | United States | Ireland | Ireland |
| Replication | Physical (full) | Physical (full) | Physical (full) | Synthetic (swap) | Physical (full) | Physical (full) | Physical (full) |
| 3-yr return p.a. | +17.7% | +26.5% | +13.9% | -73.9% | +16.7% | ||
| 5-yr return p.a. | +5.9% | +18.6% | +6.7% | +9.2% | |||
| # holdings | 67 | 77 | 1,494 | 572 | 80 | 505 | 505 |
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