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State Street® SPDR® S&P® Biotech ETF

SPDR · US78464A8707

State Street® SPDR® S&P® Biotech ETF is an exchange-traded fund (ETF) from SPDR, traded under the ticker XBI (ISIN US78464A8707). One trade buys a whole basket of holdings, so your money is spread out instead of riding on a single company. At its core it is a focused, thematic fund: it concentrates on the health care part of the market,…

· Tracks the S&P Biotechnology Select Industry Index index ?
Equity ?Unknown Physical ?United States ?
Mid-range feeOwns the shares directlyOtherBroadly spread
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SPDR fundsDomiciled in United StatesUnknownPhysically replicatedOther stocksYearly fee under 0.5%

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Fund size (AUM) ?
€9B
1-year return ?
+44.9%
Price Return · to 2026-10-07
Yearly fee (TER) ?
0.35%
All-in cost ≈ 0.00%

About this fund

What you own

The S&P Biotechnology Select Industry Index index is the benchmark this fund aims to copy. By holding it, this fund gives you a stake in around 167 companies across Other in a single purchase.

How it works

The fund actually buys every share in the index it tracks (full replication).

Read more

Owning every holding keeps things transparent — what is in the index is what the fund actually owns. It can be a touch costlier to run for indexes with thousands of tiny positions, since the fund has to buy and maintain them all. There is no swap bank involved, so there is no extra “what if the partner fails” question to weigh.

Cost

0.35%Yearly fee (TER)
0.00%All-in cost

The yearly running cost of the fund, shown as a % of your money. Lower is cheaper.

Read more

For example, a 0.20% fee works out at €0.20 a year for every €100 invested — that’s a generic illustration of the mechanic, not this fund’s own fee. It is skimmed quietly from inside the fund a little each day, so you never get a bill — but it drags on your return every year you hold. On a broad index ETF it is usually a small fraction of a percent; the gap between a cheap and a pricey fund looks tiny on day one but compounds over decades, which is why it is worth a glance.

Fund facts

Index tracked ?
S&P Biotechnology Select Industry Index
Replication ?
Physical
Full — buys every share
Launched
Jan 2006
20-year track record

Performance

45.168.892.5116140202120242026

Growth of $100 invested — the line starts at $100.

State Street® SPDR® S&P® Biotech ETF

End-of-day prices, rebased to a common start so the shapes are comparable. Past performance does not predict future results.

YTD+23.2%
1 year+44.9%
3 years+27.6%
5 years+4.0%

Return, year by year

-25.9
+7.6
+0.9
+35.4
'22'23'24'25
3 of 4 up yearsBest: 2025 +35.4%Worst: 2022 -25.9%Calendar-year total returns, in USD

How bumpy has it been?

28.4%
Volatility (1y) ?
How much the price swings year to year — lower is calmer.
-33.0%
Worst drop (3y) ?
The biggest fall from a peak over the last three years.
0.99
Return for the risk (3y) ?
Reward earned per unit of bumpiness.

The bigger picture

+18.8%
Since inception
Total growth since launch — about +3.4% a year.
+96.1%
Best 12 months
The strongest one-year stretch on record.
-42.4%
Worst 12 months
The weakest one-year stretch on record.
-54.0%
Worst fall on record ?
It clawed back in about 48 months.

What's inside

By sector ?

Health Care91.1%
Cash/Other5.9%
Consumer Staples2.0%
Corporate1.0%

The 10 biggest holdings make up 16.8% of the fund — the rest is spread across roughly 157 more companies.

Top 10 holdings

#CompanyWeight
1MODERNA INC2.2%
2TWIST BIOSCIENCE CORP2.1%
3NATERA INC1.8%
4IOVANCE BIOTHERAPEUTICS INC1.6%
5AMGEN INC1.6%
6BIOGEN INC1.6%
7ABBVIE INC1.5%
8HALOZYME THERAPEUTICS INC1.5%
9GILEAD SCIENCES INC1.5%
10CRISPR THERAPEUTICS AG1.5%

Where to buy this fund

Set from your language & location — change it if it's wrong.

Where it trades

ExchangeTickerCurrency
NYSEXBIUSD★ Primary
EUR listings
FrankfurtSSGFEUR
USD listings
B2XBIUSDUSD
B4XBIUSDUSD
E1XBIUSD
E1XBIGBPUSD
E1XBIRUBUSD
E1XBIUSDUSD
EOXBIRUBUSD
EPXBIUSDUSD
EUXBIGBPUSD
EUXBIRUBUSD
EUXBIUSDUSD
EUXBIUSD
EZXBIUSDUSD
GHSSGFUSD
GISSGFUSD
LASSGFUSD
LUSSGFUSD
MFXBI*USD
MMXBI*USD
MUXBI*USD
NYSE ArcaXBIUSD
OCXBIUSD
PEXBIUSD
THSSGFUSD
UAXBIUSD
UBXBIUSD
UCXBIUSD
UDXBIUSD
UFXBIUSD
UMXBIUSD
USXBIUSD
UTXBIUSD
UXXBIUSD
VFXBIUSD
VGXBIUSD
VJXBIUSD
VKXBIUSD
VPXBIUSD
VYXBIUSD
X2XBIGBPUSD
X2XBIUSDUSD
X9XBIUSD
X9XBIUSDUSD
XAXBIUSDUSD
XAXBIRUBUSD
XAXBIGBPUSD
XAXBIUSD
XBXBIGBPUSD
XBXBIUSDUSD
XEXBIUSDUSD
XEXBIRUBUSD
XEXBIGBPUSD
XEXBIUSD
XFXBIUSD
XFXBIGBPUSD
XFXBIRUBUSD
XFXBIUSDUSD
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XGXBIGBPUSD
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XHXBIUSD
XHXBIGBPUSD
XHXBIRUBUSD
XHXBIUSDUSD
XJXBIUSDUSD
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XJXBIGBPUSD
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XLXBIUSD
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XLXBIRUBUSD
XLXBIUSDUSD
XOXBIUSDUSD
XOXBIRUBUSD
XOXBIGBPUSD
XOXBIUSD
XQXBIUSDUSD
XQXBIRUBUSD
XQXBIGBPUSD
XQXBIUSD
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XTXBIUSD
XUXBIUSDUSD
XUXBIRUBUSD
XUXBIGBPUSD
XUXBIUSD
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XVXBIRUBUSD
XVXBIGBPUSD
XVXBIUSD
XWXBIUSD
XWXBIGBPUSD
XWXBIRUBUSD
XWXBIUSDUSD
XXXBIUSDUSD
XXXBIRUBUSD
XXXBIGBPUSD
XXXBIUSD
XZXBIUSD
XZXBIGBPUSD
XZXBIRUBUSD
XZXBIUSDUSD
For serious comparison — full data holdings, percentiles, advanced risk, tilt, flows

Full holdings

As of 2026-10-07 · the fund's own published holdings.

#CompanyWeight
1MODERNA INC2.2%
2TWIST BIOSCIENCE CORP2.1%
3NATERA INC1.8%
4IOVANCE BIOTHERAPEUTICS INC1.6%
5AMGEN INC1.6%
6BIOGEN INC1.6%
7ABBVIE INC1.5%
8HALOZYME THERAPEUTICS INC1.5%
9GILEAD SCIENCES INC1.5%
10CRISPR THERAPEUTICS AG1.5%
11TG THERAPEUTICS INC1.5%
12VERTEX PHARMACEUTICALS INC1.5%
13EXELIXIS INC1.5%
14ALNYLAM PHARMACEUTICALS INC1.4%
15REVOLUTION MEDICINES INC1.4%
16INCYTE CORP1.4%
17SPYRE THERAPEUTICS INC1.4%
18PROTAGONIST THERAPEUTICS INC1.4%
19KRYSTAL BIOTECH INC1.4%
20PTC THERAPEUTICS INC1.4%
21UNITED THERAPEUTICS CORP1.4%
22MADRIGAL PHARMACEUTICALS INC1.3%
23BIOMARIN PHARMACEUTICAL INC1.3%
24REGENERON PHARMACEUTICALS1.3%
25TRAVERE THERAPEUTICS INC1.3%
26GRAIL INC1.3%
27ALKERMES PLC1.3%
28ORUKA THERAPEUTICS INC1.3%
29INSMED INC1.3%
30NEUROCRINE BIOSCIENCES INC1.3%
31CYTOKINETICS INC1.3%
32ROIVANT SCIENCES LTD1.3%
33BRIDGEBIO PHARMA INC1.3%
34COGENT BIOSCIENCES INC1.2%
35IONIS PHARMACEUTICALS INC1.2%
36DIANTHUS THERAPEUTICS INC1.2%
37PRAXIS PRECISION MEDICINES I1.2%
38ERASCA INC1.2%
39ARROWHEAD PHARMACEUTICALS IN1.2%
40KYMERA THERAPEUTICS INC1.2%
41KODIAK SCIENCES INC1.1%
42RHYTHM PHARMACEUTICALS INC1.1%
43VAXCYTE INC1.1%
44VIKING THERAPEUTICS INC1.1%
45CG ONCOLOGY INC1.1%
46MIRUM PHARMACEUTICALS INC1.1%
47VERACYTE INC1.1%
48IMMUNITYBIO INC1.0%
49TANGO THERAPEUTICS INC1.0%
50CELCUITY INC0.9%
51RELAY THERAPEUTICS INC0.9%
52SCHOLAR ROCK HOLDING CORP0.9%
53CAREDX INC0.8%
54BEAM THERAPEUTICS INC0.8%
55ARCUTIS BIOTHERAPEUTICS INC0.8%
56ULTRAGENYX PHARMACEUTICAL IN0.8%
57HYPERLIQUID STRATEGIES0.7%
58DYNE THERAPEUTICS INC0.7%
59IMMUNOVANT INC0.7%
60RECURSION PHARMACEUTICALS A0.7%
61SELLAS LIFE SCIENCES GROUP I0.6%
62DENALI THERAPEUTICS INC0.6%
63IDEAYA BIOSCIENCES INC0.6%
64SUMMIT THERAPEUTICS INC0.6%
65VERA THERAPEUTICS INC0.6%
66NEKTAR THERAPEUTICS0.6%
67BIOCRYST PHARMACEUTICALS INC0.6%
68AGIOS PHARMACEUTICALS INC0.6%
69SAREPTA THERAPEUTICS INC0.5%
70ARCUS BIOSCIENCES INC0.5%
71NURIX THERAPEUTICS INC0.5%
72INTELLIA THERAPEUTICS INC0.5%
73CELLDEX THERAPEUTICS INC0.5%
74PALVELLA THERAPEUTICS INC0.5%
75ABSCI CORP0.5%
76ACADIA PHARMACEUTICALS INC0.5%
77VIRIDIAN THERAPEUTICS INC0.5%
78NOVAVAX INC0.5%
79UNIQURE NV0.5%
80BIOHAVEN LTD0.5%
81DISC MEDICINE INC0.5%
82SYNDAX PHARMACEUTICALS INC0.5%
83PRECIGEN INC0.4%
84ADMA BIOLOGICS INC0.4%
85VERICEL CORP0.4%
86IMMUNOME INC0.4%
87MINERALYS THERAPEUTICS INC0.4%
88INHIBRX BIOSCIENCES INC0.3%
89STOKE THERAPEUTICS INC0.3%
90XENCOR INC0.3%
91REPLIMUNE GROUP INC0.3%
92ORIC PHARMACEUTICALS INC0.3%
93ANAPTYSBIO INC0.3%
94FIRST TRACKS BIOTHERAPEU W/I0.3%
95ZENAS BIOPHARMA INC0.3%
96KURA ONCOLOGY INC0.3%
97ARRIVENT BIOPHARMA INC0.3%
98VIR BIOTECHNOLOGY INC0.3%
99TAYSHA GENE THERAPIES INC0.3%
100TYRA BIOSCIENCES INC0.2%
101MONTE ROSA THERAPEUTICS INC0.2%
102ARDELYX INC0.2%
103JADE BIOSCIENCES INC0.2%
104ANNEXON INC0.2%
105MANNKIND CORP0.2%
106CANDEL THERAPEUTICS INC0.2%
107RIGEL PHARMACEUTICALS INC0.2%
108AVALO THERAPEUTICS INC0.2%
109GERON CORP0.2%
110IMMIX BIOPHARMA INC0.2%
111CORVUS PHARMACEUTICALS INC0.2%
112BICARA THERAPEUTICS INC0.2%
113VOR BIOPHARMA INC0.2%
114JANUX THERAPEUTICS INC0.2%
115CULLINAN THERAPEUTICS INC0.2%
116OLEMA PHARMACEUTICALS INC0.2%
117VERASTEM INC0.2%
1184D MOLECULAR THERAPEUTICS IN0.2%
119HEMAB THERAPEUTICS HOLDINGS0.2%
120SAVARA INC0.2%
121ACHIEVE LIFE SCIENCES INC0.2%
122SANA BIOTECHNOLOGY INC0.2%
123CAPRICOR THERAPEUTICS INC0.1%
124ALLOGENE THERAPEUTICS INC0.1%
125DAMORA THERAPEUTICS INC0.1%
126REGENXBIO INC0.1%
127CYTOMX THERAPEUTICS INC0.1%
128IRONWOOD PHARMACEUTICALS INC0.1%
129KAILERA THERAPEUTICS INC0.1%
130ALTIMMUNE INC0.1%
131ARBUTUS BIOPHARMA CORP0.1%
132SOLID BIOSCIENCES INC0.1%
133CLIMB BIO INC0.1%
134SHATTUCK LABS INC0.1%
135MYRIAD GENETICS INC0.1%
136OCUGEN INC0.1%
137DESIGN THERAPEUTICS INC0.1%
138SAGIMET BIOSCIENCES INC A0.1%
139PRIME MEDICINE INC0.1%
140EMERGENT BIOSOLUTIONS INC0.1%
141MONOPAR THERAPEUTICS INC0.1%
142EDITAS MEDICINE INC0.1%
143AKTIS ONCOLOGY INC0.1%
144CABALETTA BIO INC0.1%
145ARS PHARMACEUTICALS INC0.1%
146VANDA PHARMACEUTICALS INC0.1%
147MIMEDX GROUP INC0.1%
148PROTHENA CORP PLC0.1%
149NEUROGENE INC0.1%
150CONTRA METSERA INC0.1%
151ASSEMBLY BIOSCIENCES INC0.1%
152OVID THERAPEUTICS INC0.1%
153FAETH THERAPEUTICS INC0.1%
154AURA BIOSCIENCES INC0.1%
155LEXEO THERAPEUTICS INC0.1%
156COMPASS THERAPEUTICS INC0.1%
157CRESCENT BIOPHARMA INC0.0%
158SSI US GOV MONEY MARKET CLASS0.0%
159BRIDGEBIO ONCOLOGY THERAPEUT0.0%
160CONTRA AKERO THERAPEUT0.0%
161CONTRA INHIBRX INC0.0%
162CONTRA MIRATI THERAPEU0.0%
163CONTRA VERVE THERAPEUT0.0%
164CONTRA BLUEPRINT MEDIC0.0%
165US DOLLAR0.0%
166OMNIAB INC 12.5 EARNOUT0.0%
167OMNIAB INC 15.00 EARNOUT0.0%

⭳ Download full holdings (CSV)

How it ranks vs peers

🪙 Cheaper than 50% of similar ETFs📈 Higher 1-yr return than 96%📈 Higher 3-yr return than 94%📈 Higher 5-yr return than 35%📊 Beat its category by 30.6% (1-yr) (category average +14.3%)📊 Beat its category by 15.4% (3-yr) (category average +12.3%)📊 Behind its category by 1.1% (5-yr) (category average +5.1%)

Versus the Equity (stocks) · Other · USD ETFs we track.

Advanced risk

1.46
Sortino (3y) ?
0.84
Calmar (3y) ?
18.3%
Downside deviation ?
67%
Up months (hit rate) ?
$169.55
52-week high ?
$103.68
52-week low ?

Concentration depth

~93 ?
Effective number of holdings

Roughly 167 companies are held, but the largest names carry most of the weight — so it behaves like ~93 equal-sized positions.

Tilt vs a world tracker

Health Care+81.8
Technology-29.2
Financials-16.3
Industrials-11.6
Consumer Discretionary-9.0
Communication Services-8.2

Percentage points over / under a broad world-equity tracker (not a licensed benchmark).

Similar funds

We found 6 funds that do much the same job as this one. To pick them we matched this fund's asset class and region, then show how close each match is below.

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Why it's similarThis is the fund on this page.
StocksUnknownPhysicalCheaper fee
Tracks a different index in the same category.
StocksUnknownPhysicalCheaper fee
Tracks a different index in the same category.
StocksUnknownPhysicalCheaper fee
Tracks a different index in the same category.
StocksUnknownPhysicalCheaper fee
Tracks a different index in the same category.
StocksUnknownPhysicalCheaper fee
Tracks a different index in the same category.
StocksUnknownPhysicalCheaper fee
Tracks a different index in the same category.
Index trackedS&P Biotechnology Select Industry IndexTechnology Select Sector IndexFTSE Developed ex US IndexFinancial Select Sector IndexHealth Care Select Sector IndexEnergy Select Sector IndexIndustrial Select Sector Index
Yearly fee (TER)0.35%0.08%0.03%0.08%0.08%0.08%0.08%
All-in cost0.00%0.00%0.00%0.00%0.00%0.00%0.00%
Fund size€9B€115.1B€58.5B€44.8B€38.5B€36.5B€28.1B
DomicileUnited StatesUnited StatesUnited StatesUnited StatesUnited StatesUnited StatesUnited States
ReplicationPhysical (full)Physical (full)Physical (full)Physical (full)Physical (full)Physical (full)Physical (full)
3-yr return p.a.+27.6%+34.9%+13.9%+17.8%+8.7%+13.9%+18.5%
5-yr return p.a.+4.0%+21.4%+6.7%+6.8%+5.5%+17.5%+10.7%
# holdings167771,49480632486

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Data as of 2026-10-07 · Source: issuer data, compiled by Finance Hamster

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